Which symptom is NOT typically associated with herpes simplex labialis?

Herpes simplex labialis, commonly known as cold sores, is characterized by specific symptoms that typically manifest during outbreaks. Vesicle formation is a hallmark of this condition; these are small fluid-filled blisters that appear on or around the lips. The local swelling is also common as the body responds to the viral infection. Additionally, serous material leaking from the vesicles occurs as they eventually rupture, releasing fluid.

Extreme fatigue, while it can be a symptom in various infections or illnesses, is not a typical symptom specifically associated with herpes simplex labialis. In the context of this condition, fatigue is not a direct result of the herpes virus activity in the oral region, which is why it stands out as the symptom that does not belong in the list of common manifestations.