Which symptom is characteristic of Lyme Disease?

The characteristic symptom of Lyme Disease is indeed an enlarging annular red ring, commonly referred to as a "bull's-eye" rash or erythema migrans. This rash typically appears as a circular red area surrounding a clearer center and can gradually expand over time. It is often the first visible sign of Lyme Disease following a tick bite, distinguishing it from other illnesses. The annular shape and the expansion of the rash are crucial indicators for medical professionals, helping in the early diagnosis and treatment of the disease.

In contrast, the other options describe symptoms that do not align with Lyme Disease. A red rash with central blisters may suggest other dermatological issues, while multiple small, itchy bumps or a burning sensation on the skin could indicate allergic reactions or other skin conditions rather than Lyme Disease. Understanding these distinctions is vital in effectively recognizing and managing Lyme Disease early on.