Which symptom could indicate a complication of cystic fibrosis?

Gallbladder disease is a recognized complication of cystic fibrosis due to the thickening of mucus that can obstruct bile ducts. In patients with cystic fibrosis, the production and flow of bile can be significantly impaired, leading to issues with fat digestion and absorption. This disruption can contribute to the development of gallstones or inflammation of the gallbladder, ultimately resulting in gallbladder disease.

While other symptoms like frequent diarrhea, skin rashes, and vision problems can occur in individuals with cystic fibrosis, they are not specifically indications of complications associated with the disease itself. Frequent diarrhea can result from pancreatic insufficiency rather than being a direct complication. Skin rashes may occur due to various reasons, including electrolyte imbalances, but they are not typically associated with cystic fibrosis's complications. Vision problems are also not commonly linked to complications arising directly from cystic fibrosis. Therefore, gallbladder disease stands out as a direct complication related to the underlying effects of cystic fibrosis on gastrointestinal function.