Which chemical mediator is known to increase pain perception during inflammation?

Prostaglandins are crucial chemical mediators that play a significant role in the inflammation process, particularly in increasing pain perception. They are produced at the site of injury or inflammation and act on the nerve endings, sensitizing them to other pain-inducing substances. This sensitization results in an increased perception of pain, making the area more sensitive and reactive to stimuli.

During inflammation, prostaglandins contribute to the classic signs of inflammation such as swelling, redness, and tenderness, emphasizing their role in pain modulation. Their production is often stimulated by various inflammatory stimuli, and they contribute not just to pain but also to fever and the regulation of vascular responses. Understanding this role is essential for identifying therapeutic targets in pain management and treatment strategies during inflammatory conditions.