What effect do leukocytes have on blood vessel permeability during inflammation?

Leukocytes, or white blood cells, play a critical role in the body's inflammatory response, particularly in the context of injury or infection. During inflammation, leukocytes are attracted to the site of injury or infection and contribute to the immune response. One of the key effects of leukocytes on blood vessels during this process is to increase permeability.

When inflammation occurs, chemical signals such as cytokines and chemokines are released, which promote the activation and migration of leukocytes to the affected area. These immune cells interact with the endothelial cells lining the blood vessels, causing them to become more permeable. This increased permeability allows for the passage of plasma proteins, immune cells, and other substances from the bloodstream into the surrounding tissue. The influx of these components is essential for mounting an effective immune response, as it helps deliver necessary materials to the site of injury, facilitates healing, and aids in the destruction of pathogens.

Thus, the role of leukocytes in increasing blood vessel permeability is crucial for effective inflammation, allowing for enhanced immune activity in the affected area and ultimately contributing to the healing process.