What condition is characterized by CNS abnormalities and significantly elevated body temperature?

Exertional heatstroke is characterized by a critical elevation in body temperature, often exceeding 104°F (40°C), alongside central nervous system abnormalities. This condition arises typically during intense physical activity, especially in hot and humid conditions, where the body's heat regulation fails and results in a dangerous rise in temperature. The CNS abnormalities may manifest as confusion, altered mental states, seizures, or even loss of consciousness, indicating the severity of the body's physiological response to overheating.

In terms of context, conditions like exertional heat exhaustion and acute exertional rhabdomyolysis do involve elevated temperatures and some level of muscle damage, but they do not typically present with the severe CNS involvement and dangerously high temperatures seen in heatstroke. Malignant hyperthermia is a genetic disorder triggered by certain anesthetics during surgery, resulting in a catastrophic increase in body temperature and muscle metabolism, but it is not precipitated by exertion in the typical sense as exertional heatstroke is. Hence, the alignment of excessively high temperatures with CNS symptoms distinctly identifies exertional heatstroke as the correct response.