How does bradykinin contribute to the inflammatory response?

Bradykinin plays a crucial role in the inflammatory response, particularly by increasing cell permeability and enhancing sensitivity to pain. It is a peptide that is released during tissue injury and inflammation. When bradykinin is present, it causes the blood vessels to dilate (vasodilation) and become more permeable. This change allows fluids, proteins, and white blood cells to exit the bloodstream and enter the affected tissues more easily, contributing to swelling and redness associated with inflammation.

Moreover, bradykinin directly stimulates nerve endings, leading to increased pain perception. This heightened sensitivity serves as a protective mechanism, alerting the body to potential harm and triggering behaviors to avoid further injury. Therefore, the role of bradykinin in increasing cell permeability and sensitivity to pain is essential for a proper and effective inflammatory response, facilitating healing and recovery in the affected area.