Duchenne muscular dystrophy is characterized by which of the following?

Duchenne muscular dystrophy (DMD) is a hereditary disease that results in the degeneration of skeletal muscles. This condition is primarily caused by a mutation in the dystrophin gene, which is critical for maintaining the structural integrity of muscle fibers. Without functional dystrophin, muscle cells become vulnerable to damage during contraction and ultimately lead to progressive muscle weakness and degeneration.

While acute respiratory failure and an enlarged heart can be complications associated with DMD as the disease progresses—due to weakened respiratory muscles and heart muscle involvement—these are not defining characteristics of the disease itself. Furthermore, increased mobility in the elderly does not apply to DMD, as the condition results in decreased mobility and independence due to muscle weakness. Therefore, understanding that DMD is characterized by hereditary factors leading to muscle degeneration is essential for recognizing its impact on individuals affected by the disorder.